Cyclacel Pharmaceuticals Inc

Cyclacel Pharmaceuticals Inc
Dundee Technopole, 1 James Lindsay Place Dundee Dundee DD1 5JJ
www.cyclacel.com
01382 206062
01382 206067
info@cyclacel.com
Description

Cyclacel Pharmaceuticals Inc is a clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialisation of novel, mechanism-targeted drugs to treat human cancers and other serious disorders.Founded in 1996 by Professor Sir David Lane, a world leader in tumour-suppressor biology, Cyclacel's aim was to build commercially on Professor Lane's discovery of the P53 ("tumour-suppressor") gene.Today Cyclacel continues to apply its core strength in cell cycle biology. The Company is advancing a pipeline of small molecule drugs designed to stop uncontrolled cell division. There are currently two clinical stage compounds in the Cyclacel pipeline, with a third one in late preclinical development.Their corporate strategy is to advance the company's oncology pipeline internally and develop non-oncology indications through collaborations. The Company plans to retain rights to its oncology programs through Phase Ibis development before considering partnering.

Products & Services

Through collaborations with leading companies, including Altana, AstraZeneca, Genzyme and GlaxoSmithKline, Cyclacel has built a lengthy pipeline of drug candidates, principally through internal discovery efforts.With a productive drug discovery engine and a large portfolio of development candidates, Cyclacel remains at the forefront of biotechnology in Dundee and international biopharmaceutical research. Their pipeline currently includes work on:Sapacitabine (CYC682), a drug involved in a cell cycle modulation.Seleciclib (CYC202), a cyclin-dependent kinase (CDK) inhibitor.CYC116, an Aurora kinase and VEGFR2 inhibitor

Skills & Expertise

The cell cycle lies at the heart of how cancer is caused. Based on recent advances, cell cycle inhibition is generating scientific and commercial interest as an approach to target cancer cells selectively, while generally sparing normally dividing cells.Cyclacel has built a leading position in cell cycle drug discovery and development. At their primary research facility, located in state-of-the-art facilities in Dundee, they continue to develop a range of novel drug candidates and anti-cancer therapies. Their key strengths include:Extensive experience in research and preclinical, clinical development and commercialisation.Recognised leaders in the field of cell cycle biology.A comprehensive pipeline of preclinical and clinical drug candidates as well as products on the market.Market prominence - the only company currently with an orally available CDK inhibitor in Phase 2 clinical trials.

Vascular Flow Technologies Ltd

Vascular Flow Technologies Ltd
Unit 1, Prospect Business Centre, Gemini Crescent Dundee Dundee DD2 1TY
www.vascular-flow.com
01382 598532
01382 598528
info@vascular-flow.com
Description

Vascular Flow Technologies is focussed on the research & development of vascular and endovascular devices with the application of Spiral Laminar Flow™ Technology and forging strategic partnerships with leading industry players.VFT has evolved into an ISO 13485 Medical Device Development company with unique insight and capabilities in pre-clinical development and testing.

Products & Services

Our capabilities - Pre-clinical development of Surgical Implants, Medical Technologies, MedTech, Medical Devices, Passive Therapeutic Devices, Cardiovascular, Peripheral Vascular devices, CFD and FMEA modelling, 3D Prototyping and Bench Flow Models.

Skills & Expertise
• Finding Product development partners or outsourcing parts of your R&D programme can enable you to react more quickly – you can call upon a pool of resource with the skills to deliver your requirements speedily, cost effectively and without increase in headcount.
 
• You will also have access to the latest technology without the related capital investment.
 
• Our background in product development ensures we have the relevant experience to understand your needs and offer innovative ways forward for your project whilst always keeping a clear eye on budget.
 
• Working with us can also mitigate risk. We work in close collaboration all the way and dovetail into your own Project Management structure as part of the team.
 
• We operate to ISO13485 certification 

Tayside Medical Sciences Centre

Tayside Medical Sciences Centre
TASC Research & Development Office, Ninewells Hospital & Medical School, Level 3
www.tasc-research.org.uk
01382 383900
01382 740122
tasctayside@nhs.net
Description

Tayside Medical Science Centre (TASC) brings together, within a single organisational framework, the existing functions of the Clinical Research Centre, the Tayside Clinical Trials Unit, the Tissue Bank, and the joint functions of the NHS Research & Development office and the University's Research & Innovation Services (in relation to clinical research). This strategic alignment will bring greater efficiency to research management and governance across the University and NHS.TASC provides clinical research support services for local researchers and industry partners. 

Products & Services

TASC’s productIs defined by the robust delivery of ethical clinical research ensuring the safety of all participants. Our product is created by researchers or industry partners and delivered with the participation of the local Tayside population. TASC Services:Providing advice on research development and governance, project registration, University of Dundee & NHS Support cost calculation (at the funding application stage), sponsorship, contracts and site agreements, generic and local review for NHS R&D approval, QA, pharmacovigilance and GCP monitoring. 

Onorach Ltd

Onorach Ltd
Prospect House, Gemini Crescent, Dundee Technology Park, Dundee, DD2 1TY
www.onorach.com
01382 561048
info@onorach.com
Description

Onorach® Clinical manage Phase I to IV clinical research studies for drug products (including biologicals (stem cells)) and medical devices using a tailored partnership approach that provides an effective and efficient route for clients and patients to benefit from the potential of their products.Onorach is headquartered in the UK, with a subsidiary (Onorach Baltics) in Latvia and a newly formed subsidiary called Onorach Innovation which is focused on using technology to improve the clinical trial process.Onorach provide clinical trial solutions to pharma companies (from emerging, virtual and SMEs to large-scale multinationals) in over 26 countries.

Products & Services

Onorach’s clinical trial services includes, but are not limited to, the following:

  • Phase I to IV clinical trial management
  • Project Management
  • Study Design & Protocol Development
  • CRF Development
  • Regulatory Submissions
  • Site Selection/Management
  • Monitoring
  • Data encryption
  • Data Management
  • Statistical Analysis
  • Central Laboratory Services
  • Quality Management & Audits
  • Pharmacovigilance Services
  • Clinical Study Report Writing
  • Consultation Services
  • Palitability Studies
  • Clinical Trial Supplies
  • Training
Skills & Expertise

Onorach can deliver solutions to clinical challenges in the development of products and/or technologies across a very wide range of therapeutic areas such as cardiology; neurology; paediatrics; rheumatology and endocrinology.Onorach Innovation was set-up to identify, develop and market a range of clinical trial-focused, modular software-based products that increase organisational productivity and responsiveness, whilst reducing time, cost and human error.At the centre of Onorach Innovation is a philosophy of eDIB “electronically Doing It Better”. All the products and services offered by Onorach Innovation fit within the eDIB concept:patFINDER – Specialist data-mining software that filters electronic medical records to find the right patient groups/locations.rightSITE – Onroach’s pre-qualified sites worldwide for conducting clinical trials.piFINDER – Onorach’s service for finding Principal Investigators in less than 72 hours (versus 5 working days industry average).optiSTUDY – Onorach’s clinical & medical liaison service shortens time to ‘peak study optimisation’ and research completion.encryptiDATA – Secure e-Form data capture system combining the simplicity of a ballpoint pen with the security of encrypted digital data capture.

Freshwater Laboratory

Freshwater Laboratory
Faskally Pitlochry Perthshire PH16 5LB
www.gov.scot/marinescotland
01224 876544
01796 473 52
marinescotland@gov.scot
Description

The freshwater fisheries activities of the Scottish Government are the responsibility of the Marine Scotland Freshwater Fisheries Laboratory (FFL), Pitlochry, on the shores of Loch Faskally in Perthshire.The principal task of the FFL is to provide scientific advice to the Scottish Government on all aspects of the Scottish fisheries for migratory and fresh water species. Work on salmon and sea trout forms the bulk of the research programme, because of the high value of these species and their heavy requirements for stock management advice.

Products & Services

Scientific advice to the Scottish Government and others with fishery and environmental management responsibilities in Scotland.

Skills & Expertise

 - Fisheries and environmental science. - Dynammic of exploited migratory salmonid populations, ecology of Atlantic salmon at sea. - Facilities & Equipment - Analytical, experiment fisheries and monitored river facilities backed by up-to-date computer and modelling expertise.

Entrust Clinical People

Entrust Clinical People
River Court, 5 West Victoria, Dock Road, Dundee, DD1 3JT
www.entrustpeople.co.uk
01224 907990
info@entrustpeople.co.uk
Description

Entrust People is a privately owned resourcing consultancy headquartered in the North East of Scotland with offices across the UK, which has combined 24 years of experience in human resource provisioning and resource planning.Entrust Clinical People focuses on the convergence between science and technology with a specialisation in resourcing for Clinical research, bioinformatics, biotechnology and medical technology. This is the first dedicated resourcing service of this kind in Scotland.

Products & Services

Entrust People offers its customers flexibility when it comes to developing staffing solutions which integrate seamlessly into each client business.  The contractor solution offers a flexible approach for short, medium and longer term assignments, providing top talent into workplaces where the individual offers expertise and knowledge of the space, at the same time, working to set criteria and key timelines.

Dundee Cancer Centre

Dundee Cancer Centre
Jacqui Wood Cancer Centre, James Arrott Drive, Dundee, DD1 9SY
http://cancercentre.dundee.ac.uk/
01382 383140
DundeeCancerCentre@dundee.ac.uk
Description

Dundee Cancer Centre provides a hub to facilitate collaboration and communication of cancer-related activities funded by Cancer Research UK and others across the University of Dundee, NHS Tayside and partner organisations.Through targeted support for training and translational research, the DCC harnesses world-leading cancer research and clinical practice, promotes health equity, and supports more rapid transformation of research outcomes into the prevention, diagnosis and treatment of cancer for the local community and beyond, both nationally and internationally.

Products & Services

In Tayside, Ninewells Hospital has been designated as a Cancer Centre, providing a full range of services for a large number of patients with commoner cancers and specialist services for less common cancers.Within the Cancer Centre, cancer services are delivered by several specialties in addition to the service provided by Oncology and Haematology.

  • General Surgery and Urology
  • Obstetrics and Gynaecology
  • General Medicine
  • Dermatology
  • ENT
  • Plastic/Oral Surgery
  • Neurosurgery
  • Orthopaedic
  • Radiotherapy Nursing Team
Skills & Expertise

Cancer research at Dundee is among the best in the UK. This has been recognised by Cancer Research UK who approved Dundee as Scotland’s first Cancer Research UK Centre. This brings together Cancer Research UK funded researchers who are distributed across the College of Medicine, Dentistry and Nursing (CMDN) and the College of Life Sciences (CLS). Successful ties to the College of Art, Science and Engineering (CASE) through the Institute for Medical Science and Technology (IMSaT) and the School of Computing and Division of Mathematics also exist.In the clinical environment there are close links between clinicians and management in NHS Tayside and the University of Dundee integrates nursing, public health and palliative care services with clinical cancer services. Based on one-stop clinics for diagnosis and an eminent pathology department there are particular strengths in surgical oncology for breast and colon cancer, radiation biology and clinical oncology (including intra-operative radiotherapy), skin cancer research from the bench to the clinic and a Centre for Pharmacogenomics and Population Research.

DNA Sequencing Services

DNA Sequencing Services
College of Life Sciences University of Dundee Dundee Scotland DD1 5EH
www.dnaseq.co.uk
01382 388019
01382 388729
info@dnaseq.co.uk
Description

We are a core DNA sequencing and fragment analysis facility based within the Medical Research Council Protein Phosphorylation Unit in the School of Life Sciences and serving laboratories within the University of Dundee and elsewhere within the UK and EU. We are located within dedicated laboratory space that forms part of the School of Life Sciences on the main campus. The revenue brought in by the work we do covers the running costs of the facility. Any additional revenue is used to help fund the academic research of our parent laboratories. This involves research into diseases such as diabetes, cancer, arthritis and Alzheimers disease. Although we are part of the MRC Unit, the facility is managed as an independent entity and we ensure strict confidentiality is maintained with regard to customer samples and results, so confidentiality can be assured. We provide a wide range of contract research products for DNA analysis and associated services. We are also willing to discuss custom projects. Please contact us to  discuss your individual requirements and how we might assist you.

Products & Services

We use the latest technology to generate the best possible data for our customers. Our range of instruments includes two Applied Biosystems 3730 DNA analyzers, one  Applied Biosystems 3730XL DNA analyzer, four Qiagen Biorobot 9600s, seven 96 well PCR machines, a nanodrop spectrophotometer, three 96 well plate spinning centrifuges,  two KingFisher Flex 96 robots, an orbital shaker for bacterial cultures, a benchtop centrifuge for pelleting bacteria from cultures and a range of electronic multi-channel pipettes.

Skills & Expertise

We have developed a great deal of expertise in DNA sequencing over many years of providing a service to the scientific community. This is particularly useful when advising customers of different approaches to use and when assisting customers with trouble-shooting. Our combined experience is over 30 years and we are always very happy to provide assistance and advice to our customers.

CIRCA Connect Ltd

CIRCA Connect Ltd
School of Computing, University of Dundee Nethergate, Dundee DD1 4HN
www.circaconnect.co.uk/
01382 385596
Description

The CIRCA team was founded by a multi-disciplinary group of academics and researchers from the universities of Dundee and St Andrews who came together overten years ago to explore ways in which computer-based technologies could help support people living with dementia.

Products & Services

CIRCA is an easy-to-use computer programme that helps support conversation between people with dementia, and their caregivers and relatives. The system contains an  extensive collection of archive photographs, video clips and popular music which is easily accessed by simply touching the screen.People with dementia, and their relatives and caregivers, can use the touchscreen to interact with and explore an extensive media database collected from some of the UK's oldest and most prestigious archives. This revolutionary system is the result of 10 years of research, with field studies conducted in care institutions throughout the UK and results reported in academic publications all over the world.

Skills & Expertise

The CIRCA team bring together expertise in the fields of design, psychology and computer science. Among other inventions, they are responsible for the development of CIRCA, the first dedicated computer-based system to support reminiscence and conversation, and the LIM Games, a series of computer games specifically designed for and with people who have dementia.

University of Dundee

University of Dundee
Research & Innovation Services, 11 Perth Road Dundee Dundee DD1 4HN
www.dundee.ac.uk/research/
01382 386766
01382 386765
research@dundee.ac.uk
Description

The University of Dundee has an international research reputation in the field of biomedical lifesciences and attracts over £50 million per annum in research funding, 90% of which is directed to the biomedical area. All life science and clinical research departments are 5/5*, the highest rating available. The University has established several multi-million pound research collaborations with the pharmaceutical industry in the areas of drug discovery, pharmacogenomics and translational medicine.Key areas of research at the University include Cancer, Diabetes, Cardiovascular Disease, Respiratory Diseases, Gene Regulation and Expression, Genomics, GutBiology, Immunology, Neurosciences, Kinase/Research & Signal Transduction. The University also has expertise in Biomedical Engineering, Medical Devices and is a centre of Health Informatics Pharmacogenomics Tissue Engineering expertise.

Products & Services

The University has a variety of services and facilities that are also open to organisations outside the University.Services available include:

  • The Finger Prints Proteomics Facility - www.dundee.ac.uk/biocentre/Fingerprints/index.html
  • DNA Sequencing Services - www.dnaseq.co.uk
  • Light Microscopy Facility (CHIPS) - www.dundee.ac.uk/lifesciences/microscopy/welcome.htm
  • DNA Analysis Facility - www.humangenetics.org.uk/dnaseq.htm
  • A full list of services based within the College of Life Sciences is available at – www.dundee.ac.uk/lifesciences/services.htm
  • [Please check with individual units to discuss individual requirements/updates to services]
  • Alzheimer’s Disease Research Centre - www.dundee.ac.uk/pharmacology/alzheime.htm
  • The Dundee group of the Alzheimer’s Disease Research Centre comprises a multidisciplinary research team which includes biomedical, social and clinical researchers.
  • The Biomedical Research Centre (BRC) - www.dundee.ac.uk/biomedres/ The BRC is a Department within the Medical College of the University of Dundee specialising in researching the role of environmental factors in human disease, and the protective adaptive response systems that have evolved.
  • Clinical Research Centre - www.dundee.ac.uk/medden. Clinical research in the prevention, diagnosis and early therapy for cancer, CVD, thoracic diseases, nutrition, diabetes, metabolic disease and neuroscience.
  • Dundee Diabetes Research Centre - www.diabetes.dundee.ac.uk. The Research Centre was created to foster and encourage research at the University among the numerous groups with a shared focus in Diabetes research.
  • Neurosciences Institute - http://www.diabetes.dundee.ac.uk. The Neurosciences Institute, which is part of the Department of Pharmacology and Neuroscience, was established to investigate the fundamental molecular mechanisms of brain function.
  • Medicines Monitoring Unit - www.dundee.ac.uk/memo/ (see separate entry). The Medicines Monitoring Unit (MEMO) is a pharmacoepidemiology research unit based within Ninewells Hospital and Medical School, at the University of Dundee.
  • The Surgical Skills Unit - www.dundee.ac.uk/surgicalskills. Training for surgeons in minimal access techniques.
  • Tayside Tissue Bank - www.tissuebank.dundee.ac.uk. The TTB holds tissue samples for use in approved research projects. Applications from other Universities and collaborative studies with other organisations can also be considered.