|Salary:||£32,236 to £35,211 Grade 7, SP 29-32.|
Duration of employment: 20 months.
We are recruiting for an exceptional individual to join us as a Post-doctoral Research Scientist within Systems Medicine / Reproductive Medicine Group, to develop and validate a screening assay for sperm ion channel dysfunction.
Infertility is estimated to affect 1:7 couples, with male factor as a sole or contributory cause in approximately 50% cases. Our studies of human sperm demonstrate that ion channel dysfunction (ICD) is common, complex and associated with impaired fertilisation at IVF (Williams et al., 2015, Brown et al., 2017, Kelly et al., 2018). Funded by Chief Scientist Office translational award, you will join a collaboration between University of Dundee and University of Abertay, to develop and validate screening tests to predict the likelihood of fertilisation failure caused by sperm ICD, using cutting-edge automated screening technologies at the National Phenotypic Screening Centre (NPSC). Evaluation of the predictive potential of the tests will be achieved by using patient sperm samples. You will work between the NPSC and the Medical School at Ninewells Hospital. Due to the nature of availability of the patient samples you may be required to work a non-standard hour pattern.
Extensive training is available within our highly collaborative, interdisciplinary environment and it is therefore not necessary to have direct experience in reproductive biology. You will be encouraged to make an intellectual contribution through data analysis/presentation and development of ideas. Preparation of manuscripts and conference presentation is expected.
The University of Dundee enjoys an international reputation for excellence that attracts top-class students and academics from across the world – with over 140 countries represented in the University community. You will be based at Ninewells Hospital and Medical School, one of Europe’s largest teaching hospitals where the School of Medicine provides outstanding opportunities in medical education and training supported by world class research facilities.
Your priorities will include:
- Development of automated assays to assess molecular and functional properties of human spermatozoa from healthy donor and patient cohorts.
- Design and implementation of standard operating procedures to validate results.
Who we’re looking for:
- PhD in a biological/life sciences subject.
- Ability to problem-solve, troubleshoot and work flexibly and independently to deadlines.
- Track record in cell-based research, preferably with experience in developing quantitative biological assays.
- Knowledge of microscopy (preferably live cell-imaging, although not essential) and flow cytometry.
- Previous involvement in successful collaborative research projects, proven ability to work as part of a team with demonstrable project management skills and an ability to multi-task.